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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They can be unusual in this malignancy in comparison with other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and seven% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A are also mutated in a small proportion of individuals. Of Be a